Dataset Information


Mus musculus

ABSTRACT: Mouse embryonic fibroblast (MEF) cells after 2, 3 or 4 days of inducible genetic deletion of Dicer1

ORGANISM(S): Mus musculus  



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The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease.

Wu Di D   Hu Yifang Y   Tong Stephen S   Williams Bryan R G BR   Smyth Gordon K GK   Gantier Michael P MP  

RNA (New York, N.Y.) 20130524 7

Recent studies have established that mutations or deletions in microRNA (miRNA) processing enzymes resulting in a global decrease of miRNA expression are frequent across cancers and can be associated with a poorer prognosis. While very popular in miRNA profiling studies, it remains unclear whether miRNA microarrays are suited or not to accurately detecting global miRNA decreases seen in cancers. In this work, we analyzed the miRNA profiles of samples with global miRNA decreases using Affymetrix  ...[more]

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