Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Mouse embryonic fibroblast (MEF) cells after 2, 3 or 4 days of inducible genetic deletion of Dicer1

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA196576 | ENA |

REPOSITORIES: ENA

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Publications

The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease.

Wu Di D   Hu Yifang Y   Tong Stephen S   Williams Bryan R G BR   Smyth Gordon K GK   Gantier Michael P MP  

RNA 20130524 7


Recent studies have established that mutations or deletions in microRNA (miRNA) processing enzymes resulting in a global decrease of miRNA expression are frequent across cancers and can be associated with a poorer prognosis. While very popular in miRNA profiling studies, it remains unclear whether miRNA microarrays are suited or not to accurately detecting global miRNA decreases seen in cancers. In this work, we analyzed the miRNA profiles of samples with global miRNA decreases using Affymetrix  ...[more]

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