Genomics

Dataset Information

59


ABSTRACT: Genome-wide analysis of liver in male and female mice

PROVIDER: PRJNA208273 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice.

Kosters Astrid A   Sun Deqiang D   Wu Hao H   Tian Feng F   Felix Julio C JC   Li Wei W   Karpen Saul J SJ  

PloS one 20130819 8


Many hepatic functions including lipid metabolism, drug metabolism, and inflammatory responses are regulated in a sex-specific manner due to distinct patterns of hepatic gene expression between males and females. Regulation for the majority of these genes is under control of Nuclear Receptors (NRs). Retinoid X Receptor alpha (RXRα) is an obligate partner for multiple NRs and considered a master regulator of hepatic gene expression, yet the full extent of RXRα chromatin binding in male and female  ...[more]

Similar Datasets

| PRJNA208275 | ENA
2015-07-28 | E-GEOD-60014 | ArrayExpress
2014-04-01 | E-GEOD-21696 | ArrayExpress
2016-11-16 | E-MTAB-4913 | ArrayExpress
2010-09-28 | E-GEOD-21777 | ArrayExpress
| GSE107435 | GEO
| GSE89091 | GEO
2013-07-03 | E-GEOD-44571 | ArrayExpress
| GSE21696 | GEO
2010-12-16 | E-MTAB-455 | ArrayExpress