Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Expression data of TAGLN-overexpressing RKO human colon cancer cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA212543 | ENA |

REPOSITORIES: ENA

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Publications

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.

Zhou Hui-Min HM   Fang Yuan-Yuan YY   Weinberger Paul M PM   Ding Ling-Ling LL   Cowell John K JK   Hudson Farlyn Z FZ   Ren Mingqiang M   Lee Jeffrey R JR   Chen Qi-Kui QK   Su Hong H   Dynan William S WS   Lin Ying Y  

BMC cancer 20160204


Transgelin is an actin-binding protein that promotes motility in normal cells. Although the role of transgelin in cancer is controversial, a number of studies have shown that elevated levels correlate with aggressive tumor behavior, advanced stage, and poor prognosis. Here we sought to determine the role of transgelin more directly by determining whether experimental manipulation of transgelin levels in colorectal cancer (CRC) cells led to changes in metastatic potential in vivo.Isogenic CRC cel  ...[more]

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