Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: HIF knockdowns in human hematopoietic stem cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA215276 | ENA |

REPOSITORIES: ENA

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Publications


Hematopoietic stem and progenitor cells (HSPCs) are exposed to low levels of oxygen in the bone marrow niche, and hypoxia-inducible factors (HIFs) are the main regulators of cellular responses to oxygen variation. Recent studies using conditional knockout mouse models have unveiled a major role for HIF-1α in the maintenance of murine HSCs; however, the role of HIF-2α is still unclear. Here, we show that knockdown of HIF-2α, and to a much lesser extent HIF-1α, impedes the long-term repopulating a  ...[more]

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