Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: HITS-CLIP of cytoplasmic SLBP RNP

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA262813 | ENA |

REPOSITORIES: ENA

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Publications

A multiprotein occupancy map of the mRNP on the 3' end of histone mRNAs.

Brooks Lionel L   Lyons Shawn M SM   Mahoney J Matthew JM   Welch Joshua D JD   Liu Zhongle Z   Marzluff William F WF   Whitfield Michael L ML  

RNA (New York, N.Y.) 20150916 11


The animal replication-dependent (RD) histone mRNAs are coordinately regulated with chromosome replication. The RD-histone mRNAs are the only known cellular mRNAs that are not polyadenylated. Instead, the mature transcripts end in a conserved stem-loop (SL) structure. This SL structure interacts with the stem-loop binding protein (SLBP), which is involved in all aspects of RD-histone mRNA metabolism. We used several genomic methods, including high-throughput sequencing of cross-linked immunoprec  ...[more]

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