Dataset Information


Homo sapiens

ABSTRACT: PBMC gene expression of early onset of the first demyelinating event of acute optic neuritis

ORGANISM(S): Homo sapiens  



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The role of B cells in the early onset of the first demyelinating event of acute optic neuritis.

Feldman Anna A   Gurevich Michael M   Huna-Baron Ruth R   Achiron Anat A  

Investigative ophthalmology & visual science 20150115 2

PURPOSE: We evaluated the molecular pathways that operate in the early phase of acute optic neuritis (ON) by studying gene expression profiles of peripheral blood mononuclear cells (PBMCs) subpopulations, including CD19(+) B cells, CD14(+) macrophages, and CD4(+) and CD8(+) T cells. METHODS: Samples of PBMC subpopulations were obtained from 18 MS patients within 96 hours of the acute onset of the first demyelinating event of ON, and from 14 age- and sex-matched healthy subjects. High throughput  ...[more]

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