Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Microarray analyses of the effects of prenatal metformin exposure on the gene expression profile of liver, brain and subcutaneous adipose tissue of neonatal mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA264537 | ENA |

REPOSITORIES: ENA

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Publications

Prenatal metformin exposure in a maternal high fat diet mouse model alters the transcriptome and modifies the metabolic responses of the offspring.

Salomäki Henriikka H   Heinäniemi Merja M   Vähätalo Laura H LH   Ailanen Liisa L   Eerola Kim K   Ruohonen Suvi T ST   Pesonen Ullamari U   Koulu Markku M  

PloS one 20141226 12


AIMS: Despite the wide use of metformin in metabolically challenged pregnancies, the long-term effects on the metabolism of the offspring are not known. We studied the long-term effects of prenatal metformin exposure during metabolically challenged pregnancy in mice. MATERIALS AND METHODS: Female mice were on a high fat diet (HFD) prior to and during the gestation. Metformin was administered during gestation from E0.5 to E17.5. Male and female offspring were weaned to a regular diet (RD) and sub  ...[more]

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