Dataset Information


Mus musculus

ABSTRACT: Microarray analyses of the effects of prenatal metformin exposure on the gene expression profile of liver, brain and subcutaneous adipose tissue of neonatal mice

ORGANISM(S): Mus musculus  



altmetric image


Prenatal metformin exposure in a maternal high fat diet mouse model alters the transcriptome and modifies the metabolic responses of the offspring.

Salomäki Henriikka H   Heinäniemi Merja M   Vähätalo Laura H LH   Ailanen Liisa L   Eerola Kim K   Ruohonen Suvi T ST   Pesonen Ullamari U   Koulu Markku M  

PloS one 20141226 12

AIMS: Despite the wide use of metformin in metabolically challenged pregnancies, the long-term effects on the metabolism of the offspring are not known. We studied the long-term effects of prenatal metformin exposure during metabolically challenged pregnancy in mice. MATERIALS AND METHODS: Female mice were on a high fat diet (HFD) prior to and during the gestation. Metformin was administered during gestation from E0.5 to E17.5. Male and female offspring were weaned to a regular diet (RD) and sub  ...[more]

Similar Datasets

2014-12-11 | E-GEOD-62612 | ArrayExpress
| GSE121604 | GEO
| GSE121603 | GEO
| GSE107894 | GEO
2011-12-16 | E-GEOD-34464 | ArrayExpress
2020-01-09 | PXD014050 | Pride
2016-07-03 | E-MTAB-3791 | ArrayExpress
2018-11-14 | E-MTAB-6255 | ArrayExpress
2012-03-15 | E-GEOD-34302 | ArrayExpress
2015-07-17 | PXD000564 | Pride