Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Expression data from healthy human PB B cell subsets

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA269791 | ENA |

REPOSITORIES: ENA

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Publications

Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions.

Seifert Marc M   Przekopowitz Martina M   Taudien Sarah S   Lollies Anna A   Ronge Viola V   Drees Britta B   Lindemann Monika M   Hillen Uwe U   Engler Harald H   Singer Bernhard B BB   Küppers Ralf R  

Proceedings of the National Academy of Sciences of the United States of America 20150126 6


The generation and functions of human peripheral blood (PB) IgM(+)IgD(+)CD27(+) B lymphocytes with somatically mutated IgV genes are controversially discussed. We determined their differential gene expression to naive B cells and to IgM-only and IgG(+) memory B cells. This analysis revealed a high similarity of IgM(+)(IgD(+))CD27(+) and IgG(+) memory B cells but also pointed at distinct functional capacities of both subsets. In vitro analyses revealed a tendency of activated IgM(+)IgD(+)CD27(+)  ...[more]

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