Dataset Information


Homo sapiens

ABSTRACT: Expression data from healthy human PB B cell subsets

ORGANISM(S): Homo sapiens  



altmetric image


Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions.

Seifert Marc M   Przekopowitz Martina M   Taudien Sarah S   Lollies Anna A   Ronge Viola V   Drees Britta B   Lindemann Monika M   Hillen Uwe U   Engler Harald H   Singer Bernhard B BB   Küppers Ralf R  

Proceedings of the National Academy of Sciences of the United States of America 20150126 6

The generation and functions of human peripheral blood (PB) IgM(+)IgD(+)CD27(+) B lymphocytes with somatically mutated IgV genes are controversially discussed. We determined their differential gene expression to naive B cells and to IgM-only and IgG(+) memory B cells. This analysis revealed a high similarity of IgM(+)(IgD(+))CD27(+) and IgG(+) memory B cells but also pointed at distinct functional capacities of both subsets. In vitro analyses revealed a tendency of activated IgM(+)IgD(+)CD27(+)  ...[more]

Similar Datasets

2018-01-01 | S-EPMC6055354 | BioStudies
2007-01-01 | S-EPMC2531291 | BioStudies
1000-01-01 | S-EPMC1526567 | BioStudies
2006-01-01 | S-EPMC1317879 | BioStudies
2013-01-01 | S-EPMC3743458 | BioStudies
2012-01-01 | S-EPMC3284330 | BioStudies
2014-01-01 | S-EPMC4133621 | BioStudies
1000-01-01 | S-EPMC1690963 | BioStudies
2019-01-01 | S-EPMC6381157 | BioStudies
2010-01-01 | S-EPMC2877021 | BioStudies