Dataset Information


Danio rerio

ABSTRACT: Transcriptional profiling of zebrafish embryos developmentally exposed to oxygenated PAHs 1,9-benz-10-anthrone and benzanthracene-7,12-dione

ORGANISM(S): Danio rerio  



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Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs.

Goodale B C BC   La Du J J   Tilton S C SC   Sullivan C M CM   Bisson W H WH   Waters K M KM   Tanguay R L RL  

Toxicological sciences : an official journal of the Society of Toxicology 20150703 2

Polycyclic aromatic hydrocarbons (PAHs) are priority environmental contaminants that exhibit mutagenic, carcinogenic, proinflammatory, and teratogenic properties. Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. Like parent PAHs, OPAHs e  ...[more]

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