Dataset Information


Mus musculus

ABSTRACT: A comprehensive examination of dynamic gene expression changes in the mouse brain during pregnancy and the postpartum period

ORGANISM(S): Mus musculus  



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An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period.

Ray Surjyendu S   Tzeng Ruei-Ying RY   DiCarlo Lisa M LM   Bundy Joseph L JL   Vied Cynthia C   Tyson Gary G   Nowakowski Richard R   Arbeitman Michelle N MN  

G3 (Bethesda, Md.) 20151123 1

The developmental transition to motherhood requires gene expression changes that alter the brain to drive the female to perform maternal behaviors. We broadly examined the global transcriptional response in the mouse maternal brain, by examining four brain regions: hypothalamus, hippocampus, neocortex, and cerebellum, in virgin females, two pregnancy time points, and three postpartum time points. We find that overall there are hundreds of differentially expressed genes, but each brain region and  ...[more]

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