Project description:Crude extracts of Moorea producens JHB (with blank solvent controls), grown under normal conditions or with excess sodium iodide, and run by LCMS on a Thermo LTQ FT and LCQ Advantage, respectively. Isolated pure compound mzXML files from the LTQ FT by direct nanomate injection.
Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
