Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role During Repair Kinetics after Selective Club Cell Ablation

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA348750 | ENA |

REPOSITORIES: ENA

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Publications

Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.

López Icíar P IP   Piñeiro-Hermida Sergio S   Pais Rosete S RS   Torrens Raquel R   Hoeflich Andreas A   Pichel José G JG  

PloS one 20161118 11


Regeneration of lung epithelium is vital for maintaining airway function and integrity. An imbalance between epithelial damage and repair is at the basis of numerous chronic lung diseases such as asthma, COPD, pulmonary fibrosis and lung cancer. IGF (Insulin-like Growth Factors) signaling has been associated with most of these respiratory pathologies, although their mechanisms of action in this tissue remain poorly understood. Expression profiles analyses of IGF system genes performed in mouse l  ...[more]

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