Dataset Information


Homo sapiens

ABSTRACT: Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists [ExVivo]

ORGANISM(S): Homo sapiens  



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Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists.

Metcalf Talibah U TU   Wilkinson Peter A PA   Cameron Mark J MJ   Ghneim Khader K   Chiang Cindy C   Wertheimer Anne M AM   Hiscott John B JB   Nikolich-Zugich Janko J   Haddad Elias K EK  

Journal of immunology (Baltimore, Md. : 1950) 20170710 4

Age-related alterations in immunity have been linked to increased incidence of infections and decreased responses to vaccines in the aging population. Human peripheral blood monocytes are known to promote Ag presentation and antiviral activities; however, the impact of aging on monocyte functions remains an open question. We present an in-depth global analysis examining the impact of aging on classical (CD14+CD16-), intermediate (CD14+CD16+), and nonclassical (CD14dimCD16+) monocytes. Monocytes  ...[more]

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