Genomics

Dataset Information

235

Mus musculus


ABSTRACT: The RNA-binding protein Sfpq regulates long neuronal genes in transcriptional elongation [RNA-seq]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA378772 | ENA |

REPOSITORIES: ENA

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Publications


Genes specifically expressed in neurons contain members with extended long introns. Longer genes present a problem with respect to fulfilment of gene length transcription, and evidence suggests that dysregulation of long genes is a mechanism underlying neurodegenerative and psychiatric disorders. Here, we report the discovery that RNA-binding protein Sfpq is a critical factor for maintaining transcriptional elongation of long genes. We demonstrate that Sfpq co-transcriptionally binds to long int  ...[more]

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