Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA400446 | ENA |

REPOSITORIES: ENA

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Publications

The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells.

Huggins Ian J IJ   Bos Tomas T   Gaylord Olivia O   Jessen Christina C   Lonquich Brianna B   Puranen Angeline A   Richter Jenna J   Rossdam Charlotte C   Brafman David D   Gaasterland Terry T   Willert Karl K  

Nature communications 20171018 1


The WNT/β-catenin signaling pathway is a prominent player in many developmental processes, including gastrulation, anterior-posterior axis specification, organ and tissue development, and homeostasis. Here, we use human pluripotent stem cells (hPSCs) to study the dynamics of the transcriptional response to exogenous activation of the WNT pathway. We describe a mechanism involving the WNT target gene SP5 that leads to termination of the transcriptional program initiated by WNT signaling. Integrat  ...[more]

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