Dataset Information


Mus musculus

ABSTRACT: Effect of aging on the global gene expression profiles of mouse olfactory neuroepithelium

ORGANISM(S): Mus musculus  



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Reduction of Proliferating Olfactory Cells and Low Expression of Extracellular Matrix Genes Are Hallmarks of the Aged Olfactory Mucosa.

Ueha Rumi R   Shichino Shigeyuki S   Ueha Satoshi S   Kondo Kenji K   Kikuta Shu S   Nishijima Hironobu H   Matsushima Kouji K   Yamasoba Tatsuya T  

Frontiers in aging neuroscience 20180327

Background: The incidence of olfactory impairment increases with age; however, the detailed molecular and cellular mechanisms underlying this increase are yet to be determined. Methods: We examined the influence of aging on olfactory receptor neurons (ORNs), which are maintained by a unique stem cell system, from olfactory progenitor cells to mature ORNs, by histological comparisons of the physiological status of the olfactory epithelium between young adult and aged mice. Furthermore, we clarifi  ...[more]

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