Genomics

Dataset Information

235

Defects in T cell independent B cell differentiation in the absence of EZH2


ABSTRACT: Defects in T cell independent B cell differentiation in the absence of EZH2

PROVIDER: PRJNA400474 | ENA |

REPOSITORIES: ENA

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Publications

EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production.

Guo Muyao M   Price Madeline J MJ   Patterson Dillon G DG   Barwick Benjamin G BG   Haines Robert R RR   Kania Anna K AK   Bradley John E JE   Randall Troy D TD   Boss Jeremy M JM   Scharer Christopher D CD  

Journal of immunology (Baltimore, Md. : 1950) 20171229 3


Epigenetic remodeling is required during B cell differentiation. However, little is known about the direct functions of epigenetic enzymes in Ab-secreting cells (ASC) in vivo. In this study, we examined ASC differentiation independent of T cell help and germinal center reactions using mice with inducible or B cell-specific deletions of Ezh2 Following stimulation with influenza virus or LPS, Ezh2-deficient ASC poorly proliferated and inappropriately maintained expression of inflammatory pathways,  ...[more]

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