Genomics

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Enzymatic or in vivo installation of propargyl groups in combination with click chemistry enables enrichment and detection of methyltransferase target sites in RNA


ABSTRACT: Enzymatic or in vivo installation of propargyl groups in combination with click chemistry enables enrichment and detection of methyltransferase target sites in RNA

PROVIDER: PRJNA430372 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR6497880.fastq.gz Fastqsanger.gz
SRR6497890.fastq.gz Fastqsanger.gz
SRR6497881.fastq.gz Fastqsanger.gz
SRR6497891.fastq.gz Fastqsanger.gz
SRR6497882.fastq.gz Fastqsanger.gz
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Publications

Enzymatic or In Vivo Installation of Propargyl Groups in Combination with Click Chemistry for the Enrichment and Detection of Methyltransferase Target Sites in RNA.

Hartstock Katja K   Nilges Benedikt S BS   Ovcharenko Anna A   Cornelissen Nicolas V NV   Püllen Nikolai N   Lawrence-Dörner Ann-Marie AM   Leidel Sebastian A SA   Rentmeister Andrea A  

Angewandte Chemie (International ed. in English) 20180322 21


m<sup>6</sup> A is the most abundant internal modification in eukaryotic mRNA. It is introduced by METTL3-METTL14 and tunes mRNA metabolism, impacting cell differentiation and development. Precise transcriptome-wide assignment of m<sup>6</sup> A sites is of utmost importance. However, m<sup>6</sup> A does not interfere with Watson-Crick base pairing, making polymerase-based detection challenging. We developed a chemical biology approach for the precise mapping of methyltransferase (MTase) target  ...[more]

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