Genomics

Dataset Information

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MeCP2 represses the rate of transcriptional initiation of highly methylated long genes (RNA-Seq I)


ABSTRACT: MeCP2 represses the rate of transcriptional initiation of highly methylated long genes (RNA-Seq I)

PROVIDER: PRJNA526675 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR8714120.fastq.gz Fastqsanger.gz
SRR8714130.fastq.gz Fastqsanger.gz
SRR8714140.fastq.gz Fastqsanger.gz
SRR8714150.fastq.gz Fastqsanger.gz
SRR8714160.fastq.gz Fastqsanger.gz
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Publications


Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastating neurodevelopmental disorder Rett syndrome. It has been challenging to understand how MeCP2 regulates transcription because MeCP2 binds broadly across the genome and MeCP2 mutations are associated with widespread small-magnitude changes in neuronal gene expression. We demonstrate here that MeCP2 represses nascent RNA transcription of highly methylated long genes in the brain through its interaction with the NCoR co-  ...[more]

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