Genomics

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High throughput small molecule screening reveals NRF2-dependent and -independent pathways of cellular stress resistance


ABSTRACT: High throughput small molecule screening reveals NRF2-dependent and -independent pathways of cellular stress resistance

PROVIDER: PRJNA535420 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR8954690.fastq.gz Fastqsanger.gz
SRR8954700.fastq.gz Fastqsanger.gz
SRR8954710.fastq.gz Fastqsanger.gz
SRR8954691.fastq.gz Fastqsanger.gz
SRR8954701.fastq.gz Fastqsanger.gz
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Publications


Aging is the dominant risk factor for most chronic diseases. Development of antiaging interventions offers the promise of preventing many such illnesses simultaneously. Cellular stress resistance is an evolutionarily conserved feature of longevity. Here, we identify compounds that induced resistance to the superoxide generator paraquat (PQ), the heavy metal cadmium (Cd), and the DNA alkylator methyl methanesulfonate (MMS). Some rescue compounds conferred resistance to a single stressor, while ot  ...[more]

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