Genomics

Dataset Information

14

Nrf2 Knockout vs. Wildtype mice


ABSTRACT: Nrf2 Knockout vs. Wildtype mice

PROVIDER: PRJNA87883 | ENA |

REPOSITORIES: ENA

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Publications

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice.

Li Jiang J   Stein Thor D TD   Johnson Jeffrey A JA  

Physiological genomics 20040811 3


Systemic lupus erythematosus (SLE) is an autoimmune disorder with immune-complex deposition that affects multiple organs. Previous studies have suggested the involvement of oxidative stress and apoptosis in SLE, but no clear link to etiology has been established. Here we show that mice deficient in a transcription factor responsible for controlling the expression of numerous detoxification and antioxidant genes develop an autoimmune disease with multiple organ pathologies that closely resembles  ...[more]

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