Dataset Information


Mus musculus

ABSTRACT: Identification of Positional Candidate Genes for Body Weight and Adiposity in Subcongenic Mice



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Identification of positional candidate genes for body weight and adiposity in subcongenic mice.

Chiu Sally S   Kim Kyoungmi K   Haus Kari A KA   Espinal Glenda M GM   Millon Lee V LV   Warden Craig H CH  

Physiological genomics 20070529 1

We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related phenotypes (Diament AL, Farahani P, Chiu S, Fisler J, Warden CH. Mamm Genome 15: 452-459, 2004). In this study, we constructed five overlapping subcongenics with smaller SPRET/Ei dono  ...[more]

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