Dataset Information


Saccharomyces cerevisiae

ABSTRACT: Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae

ORGANISM(S): Saccharomyces cerevisiae  



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Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae.

Vemuri G N GN   Eiteman M A MA   McEwen J E JE   Olsson L L   Nielsen J J  

Proceedings of the National Academy of Sciences of the United States of America 20070207 7

Respiratory metabolism plays an important role in energy production in the form of ATP in all aerobically growing cells. However, a limitation in respiratory capacity results in overflow metabolism, leading to the formation of byproducts, a phenomenon known as "overflow metabolism" or "the Crabtree effect." The yeast Saccharomyces cerevisiae has served as an important model organism for studying the Crabtree effect. When subjected to increasing glycolytic fluxes under aerobic conditions, there i  ...[more]

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