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KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

ABSTRACT: KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

PROVIDER: PRJNA732200 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14629174.fastq.gz	Fastqsanger.gz
	SRR14629175.fastq.gz	Fastqsanger.gz
	SRR14629176.fastq.gz	Fastqsanger.gz
	SRR14629177.fastq.gz	Fastqsanger.gz
	SRR14629178.fastq.gz	Fastqsanger.gz

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Similar Datasets

KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

Project description:KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

| PRJNA732199 | ENA

KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

Project description:KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

| PRJNA732201 | ENA

KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

Project description:The goal of this study is to compare transcriptome profiling (RNA-seq) of palatal tissue at E12.5 between control and Kdm6b mutant mice

2022-02-28 | GSE175381 | GEO

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.

Project description:Epigenetic regulation plays extensive roles in diseases and development. Disruption of epigenetic regulation not only increases the risk of cancer, but can also cause various developmental defects. However, the question of how epigenetic changes lead to tissue-specific responses during neural crest fate determination and differentiation remains understudied. Using palatogenesis as a model, we reveal the functional significance of Kdm6b, an H3K27me3 demethylase, in regulating mouse embryonic development. Our study shows that Kdm6b plays an essential role in cranial neural crest development, and loss of Kdm6b disturbs P53 pathway-mediated activity, leading to complete cleft palate along with cell proliferation and differentiation defects in mice. Furthermore, activity of H3K27me3 on the promoter of Trp53 is antagonistically controlled by Kdm6b, and Ezh2 in cranial neural crest cells. More importantly, without Kdm6b, the transcription factor TFDP1, which normally binds to the promoter of Trp53, cannot activate Trp53 expression in palatal mesenchymal cells. Furthermore, the function of Kdm6b in activating Trp53 in these cells cannot be compensated for by the closely related histone demethylase Kdm6a. Collectively, our results highlight the important role of the epigenetic regulator KDM6B and how it specifically interacts with TFDP1 to achieve its functional specificity in regulating Trp53 expression, and further provide mechanistic insights into the epigenetic regulatory network during organogenesis.

| S-EPMC9007587 | biostudies-literature

KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-28 | GSE175383 | GEO

KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis

Project description:The goal of this study is to assess genome-wide chromatin accessibility (ATAC-seq)of palatal tissue at E13.5

2022-02-28 | GSE175382 | GEO

RNA-seq analyses with TFDP1 knockout eHAP cells

Project description:Cas9 expressing eHAP cells were transfected with sgRNA against TFDP1. 5 days after the transfection, polyA RNA was analyzed by RNA-seq

2022-05-01 | GSE144453 | GEO

MNase-seq analyses with TFDP1 knockout eHAP cells

Project description:A genome-wide screening identified effector genes of chromatin accessibility. To investigate the functional consequences of the loss of each effector gene, we conducted Mnase-seq with eHAP cells knocked out for TFDP1.

2022-05-01 | GSE144452 | GEO

KDM6B is a conserved activator at the top of the male sex determination pathway

Project description:In mammals, commitment to the testis fate is controlled by the gene Sry on the Y chromosome; however, how Sry is regulated is not well understood. In the red-eared slider turtle, Dmrt1 acts as the primary activator of the testis pathway. Removal of the repressive histone modification H3K27me3 from Dmrt1 by the histone demethylase KDM6B is required for its activation. We hypothesized that a similar de-repression mechanism is utilized in mammals to activate the testis pathway. Using a mouse knock-out model for Kdm6b, we found that loss of Kdm6b leads to a delay in Sry activation and the development of an ovotestis. These results implicate KDM6B as a conserved regulator at the top of the sex determination cascade in both reptiles and mammals.

2025-06-05 | GSE295878 | GEO

KDM4B- and KDM6B-regulated genes in human mesenchymal stem cell osteogenic differentiation

Project description:To investigate how histone demethylases KDM4B and KDM6B may be involved in osteogenic commitment of mesenchymal stem cells (MSCs), we performed gene expression profiling and comparison on control, KDM4B- and KDM6B-knockdown MSCs at different stages of osteogenic differentiation. Human MSCs infected with scramble shRNAs, shRNAs against KDM4B or KDM6B are treated with BMP4/7 for 0, 4 and 24hrs. Total RNA were extracted from these 9 samples.

2012-07-31 | E-GEOD-36970 | biostudies-arrayexpress

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