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ProteomicsRegulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα
Progenitor cells at the basal layer of skin epidermis play an essential role in maintaining tissue homeostasis and enhancing wound repair in skin. The proliferation, differentiation, and cell death of epidermal progenitor cells have to be delicately regulated, as deregulation of this process can lea...
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD015673 | Pride
Deubiquitination Kdf1 Silac Skin Ikkα Epidermal differentiation Qe-ms 
UnknownFirst-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of Streptococcus pneumoniae.
Not available
S-EPMC6719014 | biostudies-literature
UnknownEvaluation of Differentially Expressed Genes in Leaves vs. Roots Subjected to Drought Stress in Flax (Linum usitatissimum L.).
Not available
S-EPMC10419004 | biostudies-literature
UnknownComprehensive Analysis of Differentially Expressed Genes and Epigenetic Modification-Related Expression Variation Induced by Saline Stress at Seedling Stage in Fiber and Oil Flax, Linum usitatissimum L.
Not available
S-EPMC9370232 | biostudies-literature
ProteomicsQuantitative proteomic analysis based on the isobaric tags for relative and absolute quantitation (iTRAQ) labeling in WT and NudCL2 KO-1 HEK-293 cells
Cytokinesis is a key step in the later stage of cell division to partition cellular contents into daughter cells, which undergoes precise regulation in temporal and spatial. However, the underlying mechanisms are still unclear. Here, we show that Hsp90 cochaperone, NudCL2 (NudC-like protein 2), is r...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD043570 | Pride
Hek-293 Nudcl2 Itraq 
UnknownBenzyl and benzoyl benzoic acid inhibitors of bacterial RNA polymerase-sigma factor interaction.
Not available
S-EPMC7680358 | biostudies-literature
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
ProteomicsTandem Mass Tag-based proteomics of astaxanthin-producing tobacco expressing astaxanthin synthetases from Adonis aestivalis
The synthesis of astaxanthin leads to growth retardation in tobacco. Meanwhile, irregular mosaic pigmentation randomly appears on the leaves of astaxanthin-producing tobacco. The purpose of this project is to elucidate the mechanism of growth retardation in astaxanthin-producing tobacco and to compa...
ORGANISM(S): Nicotiana Tabacum 
2024-03-05 | PXD050349 |
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