{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD1024"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Study Component","organisation","Biosample","Image correlation","Associations","Image acquisition"],"pubmed_authors":["Richard Benninger"],"additional_accession":[]},"is_claimable":false,"name":"Beta-cell Intrinsic Dynamics Rather than Gap Junction Structure Dictates Subpopulations in the Islet Functional Network","description":"Diabetes is caused by the inability of electrically coupled, functionally heterogeneous β-cells within the pancreatic islet to provide adequate insulin secretion. Functional networks have been used to represent synchronized oscillatory [Ca2+] dynamics and to study β-cell subpopulations, which play an important role in driving islet function. The mechanism by which highly synchronized β-cell subpopulations drive islet function is unclear. We used experimental and computational techniques to investigate the relationship between functional networks, structural (gap-junction) networks, and intrinsic β-cell dynamics in slow and fast oscillating islets. Highly synchronized subpopulations in the functional network were differentiated by intrinsic dynamics, including metabolic activity and KATP ch","dates":{"release":"2024-01-22T00:00:00Z","modification":"2024-02-15T23:28:06.967Z","creation":"2024-01-19T16:09:56.877Z"},"accession":"S-BIAD1024","cross_references":{}}