bioimagesUnknownhttps://www.ebi.ac.uk/biostudies/studies/S-BIAD1030bioimagesSpecimenImage analysisFundingStudy ComponentorganisationBiosampleImage correlationAssociationsImage acquisitionSima StroganovMichal NeemanfalseThe differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placentaBackground Fetal growth restriction (FGR) is a pregnancy complication in which a newborn fails to achieve its growth potential, increasing the risk of perinatal morbidity and mortality. Chronic maternal gestational hypoxia, as well as placental insufficiency are associated with increased FGR incidence; however, the molecular mechanisms underlying FGR remain unknown. Methods Pregnant mice were subjected to acute or chronic hypoxia (12.5% O2) resulting in reduced fetal weight. Placenta oxygen transport was assessed by blood oxygenation level dependent (BOLD) contrast magnetic resonance imaging (MRI). The placentae were analyzed via immunohistochemistry and in situ hybridization. Human placentae were selected from FGR and matched controls and analyzed by immunohistochemistry (IHC). M2024-01-31T00:00:00Z2024-01-30T10:11:09.009Z2024-01-30T10:11:09.009ZS-BIAD1030