bioimagesUnknownhttps://www.ebi.ac.uk/biostudies/studies/S-BIAD1119bioimagesSpecimenStudy ComponentorganisationBiosampleAssociationsImage acquisitionAnne RiosfalseSource Images A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgeryAchieving complete tumor resection is challenging and can be improved by real-time fluorescence guided surgery with molecular-targeted probes. However, pre-clinical identification and validation of probes presents a lengthy process that is traditionally performed in animal models and hampered by inter- and intra-tumoral heterogeneity in target expression. To screen multiple probes at patient scale, we developed a multispectral real-time 3D imaging platform that implements organoid technology to effectively model patient tumor heterogeneity and, importantly, healthy human tissue binding. 2024-04-25T00:00:00Z2024-04-26T08:49:15.838Z2024-04-15T15:02:01.571ZS-BIAD1119