{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD1239"],"repository":["bioimages"],"figure_sub":["Specimen","Study Component","organisation","Biosample","Associations","Image acquisition"],"pubmed_authors":["Claude Libert","Céline Van Dender"],"additional_accession":[]},"is_claimable":false,"name":"A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death","description":"The CLP model was used to study polymicrobial sepsis, with sham as a control. Mice were subjected to sham or CLP procedure, and 6h, 24h and 48h later, livers were isolated for immunohistochemisty. As a control, wildtype control (Hnf4aflfl) and liver-specific HNF4a knockout (Hnf4aLiver-i-KO) mice were included, all of which were injected with tamoxifen for 5 consecutive days. Livers were isolated for immunohistochemistry 3 days after the last tamoxifen injection. The images were stained with DAPI (nuclei - blue) and an HNF4a antibody (red) and visualized with Axioscan.Z1 Slide scanner (Zeiss), using a Plan-Apochromat 10x/0.45 M27 objective lens at a pixel size of 0.650 µm.","dates":{"release":"2024-06-25T00:00:00Z","modification":"2024-06-25T10:23:46.462Z","creation":"2024-06-25T10:23:46.462Z"},"accession":"S-BIAD1239","cross_references":{}}