{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD1280"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Funding","Study Component","organisation","Biosample","Image correlation","Associations","Image acquisition"],"pubmed_authors":["Morgan J. Linahon","Hui Wang","Peter S. Thorne","Michael S. Chimenti","Xueshu Li","Michael E. Dailey","Aloysius J. Klingelhutz","Hans-Joachim Lehmler","Amanda J. Bullert","James A. Ankrum","Hanna E. Stevens","Andrea Adamcakova-Dodd"],"additional_accession":[]},"is_claimable":false,"name":"Effects of PCB52 (2,2',5,5'-Tetrachlorobiphenyl) on the Rat Brain After Subacute Nose-Only Inhalation Exposure ","description":"A semi-volatile polychlorinated biphenyl (PCB) congener, PCB52, is present in the indoor air of schools; however, the effects of inhaled PCB52 on the brain have not been investigated. This study exposed male Sprague-Dawley rats at 39 days of age and female rats at 42 days of age to PCB52 for 4 hours per day over 28 consecutive days through nose-only inhalation. Neurobehavioral tests were conducted during the last 5 days of exposure. The total estimated PCB52 exposures after 28 days were 1080±20 µg/kg BW for male rats and 1140 ± 10 µg/kg BW for female rats. PCB52 and its metabolites were detected by gas chromatography-tandem mass spectrometry in the brain, lung, and serum, with the lung showing the highest concentrations. PCB52 levels were higher in the brains of females than males. Males s","dates":{"release":"2024-10-07T00:00:00Z","modification":"2024-10-05T19:38:42.714Z","creation":"2024-07-17T14:23:59.162Z"},"accession":"S-BIAD1280","cross_references":{}}