{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD1287"],"repository":["bioimages"],"figure_sub":["Specimen","Funding","Study Component","organisation","Biosample","Associations","Image acquisition"],"pubmed_authors":["Sudip Khadka","Ivan E. Ivanov","Rasmi Cheloor Kovilakam","Chad Liu","Madhura Bhave","Ziwen Liu","Carolina Arias","Manuel D. Leonetti","Soorya Pradeep","Bo Huang","Talon Chandler","Shalin B. Mehta","Eduardo Hirata Miyasaki"],"additional_accession":[]},"is_claimable":false,"name":"Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells","description":"Understanding the dynamics and interactions of cellular components is crucial for biological research and drug discovery. Current dynamic fluorescence microscopy methods can only image a few fluorescent labels, providing a limited view of these complex processes. We developed Mantis, a high-throughput 3D microscope that maps interactions among components of dynamic cell systems. Mantis combines light-sheet fluorescence imaging of multiple fluorophores with quantitative label-free microscopy and is complemented by shrimPy, our open-source software for high-throughput data acquisition and high-performance analysis. Mantis enabled simultaneous 3D time-lapse imaging of 20 cell lines and quantitative analysis of responses to perturbations like viral infection at single-cell resolution. This app","dates":{"release":"2024-07-30T00:00:00Z","modification":"2024-08-09T16:45:19.3Z","creation":"2024-07-23T22:37:32.227Z"},"accession":"S-BIAD1287","cross_references":{}}