{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD1324"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Funding","Study Component","organisation","Biosample","Associations","Image acquisition"],"pubmed_authors":["Jing Chen","Christian Stockmann"],"additional_accession":[]},"is_claimable":false,"name":"Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas","description":"A hallmark feature of pancreatic ductal adenocarcinoma (PDAC) is massive intratumoral fibrosis, designated as desmoplasia. Desmoplasia is characterized by the expansion of cancer-associated fibroblasts (CAFs) and a massive increase in extracellular matrix (ECM). During fibrogenesis, distinct genes become reactivated specifically in fibroblasts, e.g., the disintegrin metalloprotease, ADAM12. Previous studies have shown that immunotherapeutic ablation of ADAM12+ cells reduces fibrosis in various organs. In preclinical mouse models of PDAC, we observe ADAM12 expression in CAFs as well as in tumor cells but not in healthy mouse pancreas. Therefore, we tested prophylactic and therapeutic vaccination against ADAM12 in murine PDAC and observed delayed tumor growth along with a reduction in CAFs a","dates":{"release":"2024-10-29T00:00:00Z","modification":"2024-09-25T07:54:27.16Z","creation":"2024-08-16T14:10:46.685Z"},"accession":"S-BIAD1324","cross_references":{}}