{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD1368"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Study Component","organisation","Biosample","Associations","Image acquisition"],"pubmed_authors":["Emily B. Mobley"],"additional_accession":[]},"is_claimable":false,"name":"Chromenylium Star Polymers: Merging Water Solubility and Stealth Properties with Shortwave Infrared Emissive Fluorophores","description":"Fluorescence imaging in the shortwave infrared (SWIR) region has emerged as a vital tool for studying mammals. SWIR emissive polymethine dyes are well suited to this endeavor; however, advancing in vivo imaging utility with these dyes is primarily limited by hydrophobicity and/or non-specific protein adsorption. Herein, we take a distinct approach to combine hydrophilicity and stealth behavior to construct bright, SWIR emissive chromenylium fluorophores by employing a well-defined poly(2-methyl-2-oxazoline) (POx) star polymer architecture, which we refer to as chromenylium stars, or “CStars.” Of these polymer-shielded dyes, the variant containing five POx chains (CStar30) boasts particularly enhanced aqueous solubility and SWIR brightness, enabling high resolution SWIR imaging in mice. The","dates":{"release":"2024-09-21T00:00:00Z","modification":"2025-01-14T23:19:32.404Z","creation":"2024-09-18T17:31:29.034Z"},"accession":"S-BIAD1368","cross_references":{}}