bioimagesUnknownhttps://www.ebi.ac.uk/biostudies/studies/S-BIAD1834bioimagesSpecimenStudy ComponentorganisationBiosampleAssociationsImage acquisitionDANAY CIBRIANfalseRestricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response (EMM-2024-19430)The L-Leu amino acid transporter SLC7A5 has become an important target in inflammation and cancer. However, its role in acute graft-versus-host disease (aGVHD) and graft versus tumor (GVT) remains unexplored. We demonstrate that SLC7A5 deletion affected T cell activation, expansion and survival, and reduced IFNγ and granzyme B expression, thus controlling aGVHD, but without effect on tumor growth. On the other hand, dietary restriction of L-Leu reduced aGVHD by controlling T cell expansion, inducing apoptosis, and affecting granzyme B secretion. However, CD8 T cells did not fail to activate and express IFNγ in the absence of L-Leu, and showed an increased proportion of central memory T cells, which contributed to the GVT response. Deletion of SLC7A5 in T cells compromises mTORC1, glycolysi2025-04-20T00:00:00Z2026-04-13T15:03:42.101Z2025-04-15T12:13:13.037ZS-BIAD1834