{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Benjamin F. Combes"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD3402"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Study Component","Biosample","organisation","Image correlation","Associations","Image acquisition"],"pubmed_authors":[" Liqin Yang","Yi Chen","Roger M. Nitsch","Marco Reisert","Tian Zeng","Alicia K. Rosenau","Martin T. Henrich","Wolfgang H. Oertel","Sepp Kollmorgen","Ruiqing Ni","Rong Chen","Fanni F. Geibl","Jie Lu","Xunbin Wei","Hongjiang Wei","Theofanis Karayannis","Maria Karatsoli","Ted M. Dawson","Christoph Hock","Benjamin F. Combes","Sihan Dong","Valina L. Dawson","Peter R Nilsson","Daniel Razansky","Axel Rominger","Kuangyu Shi"],"additional_accession":[]},"is_claimable":false,"name":"[Historical Versions Pending Deletion] Multiscale brain-wide mapping of α-synuclein-driven dopaminergic degeneration and white matter\nimpairment in α-synucleinopathy mice","description":"Citation: [Multi-modal imaging analysis of Parkinsonian mice reveals region-specific alterations in the substantia nigra]\n\nThe spatiotemporal relationships among α-synuclein inclusion formation, dopaminergic degeneration, and white\nmatter microstructural changes remain poorly defined. To address this, we unilaterally injected preformed fibrils\n(PFFs) or monomeric α-synuclein into the substantia nigra pars compacta (SNc) of wild-type mice. At 12 and 20\nweeks post-injection (wpi), we performed ex vivo magnetic resonance imaging (MRI) at 9.4T to assess\nmicrostructural, volumetric and paramagnetic changes, along with light-sheet microscopy (LSM) to map α-\nsynuclein aggregates, and dopaminergic neuron at single-cell resolution across the whole brain. We developed a\nPython-based, automated regis","dates":{"release":"2026-05-09T00:00:00Z","modification":"2026-08-07T01:04:04.828Z","creation":"2026-05-09T09:48:57.734Z"},"accession":"S-BIAD3402","cross_references":{}}