{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Siddharth Acharya"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD3409"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Funding","Study Component","Biosample","organisation","Image correlation","Associations","Image acquisition"],"pubmed_authors":["Joshua J. Fisher","Sahan Jayatissa","Roger Smith","Lucy A. Bartho","Tia M. Smith","Joanna L. James","Zlatan Trifunovic","Tu'uhevaha J. Kaitu'u-Lino","James C. Bouwer","Siddharth Acharya","Veronica B. Botha","John E. Schjenken","Anthony V. Perkins","Eric Hanssen","Kirsty G. Pringle"],"additional_accession":[]},"is_claimable":false,"name":"Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta (cryo-electron tomography)","description":"Mitochondria adapt their structure through fusion and fission, yet how their morphology and cristae architecture change as cells differentiate remains unclear. The human placenta is a valuable model for studying mitochondrial diversity within a single tissue. As epithelial trophoblast cells of the placenta differentiate, their accompanying mitochondria morphologically and functionally transform. We used array tomography to characterise mitochondrial volume and network complexity. Cryo-electron tomography revealed two distinct subpopulations of mitochondria within progenitor cytotrophoblasts, and a singular, homogeneous population in the differentiated syncytiotrophoblast. We showcased the 3D topology of individual cristae through a standardised metric of “curvedness”. Proteomic analysis of","dates":{"release":"2026-05-15T00:00:00Z","modification":"2026-08-13T13:49:20.874Z","creation":"2026-05-11T03:43:04.015Z"},"accession":"S-BIAD3409","cross_references":{}}