{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["David Constant"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD3732"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Funding","Study Component","Biosample","organisation","Associations","Image acquisition"],"pubmed_authors":["Timothy Nice","David Constant"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal plasmacytoid dendritic cells preferentially produce interferon lambda contributing to localized innate immune responses","description":"The healthy intestine maintains homeostasis in part via immune responses to microbiota, which includes basal production of interferon cytokines. Previous work showed that Type III Interferon (IFN-λ) stimulates localized pockets of interferon-stimulated genes (ISGs) in the adult mouse intestinal epithelium at homeostasis that provide preemptive protection from viral pathogens. Here, we demonstrate that a major source of homeostatic IFN-λ production in the intestine is a population of epithelium-associated plasmacytoid dendritic cells (pDC). Expansion of the pDC population increases epithelial ISG expression at homeostasis, suggesting the abundance of these cells is a limiting factor in IFN-λ responses. On the other hand, depletion of pDC or bone marrow reconstitution with IFN-λ-deficient pD","dates":{"release":"2026-08-14T00:00:00Z","modification":"2026-08-14T01:00:49.321Z","creation":"2026-08-03T17:26:25.328Z"},"accession":"S-BIAD3732","cross_references":{}}