{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Zhiguang Zhao"],"journal":["Nature methods"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD56"],"repository":["bioimages"],"figure_sub":["Organization","Study type"],"pubmed_authors":["Zhuo Du","Zhiguang Zhao"],"additional_accession":[]},"is_claimable":false,"name":"A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis","description":"Complex biological processes such as embryogenesis require precise coordination of cell differentiation programs across both space and time. Using protein-fusion fluorescent reporters and four-dimensional live imaging, we present a protein expression atlas of transcription factors (TFs) mapped onto developmental cell lineages during Caenorhabditis elegans embryogenesis, at single-cell resolution. This atlas reveals a spatiotemporal combinatorial code of TF expression, and a cascade of lineage-specific, tissue-specific and time-specific TFs that specify developmental states. The atlas uncovers regulators of embryogenesis, including an unexpected role of a skin specifier in neurogenesis and the critical function of an uncharacterized TF in convergent muscle differentiation. At the systems le","dates":{"release":"2021-03-24T00:00:00Z","publication":"2021","modification":"2023-04-11T00:46:23.208Z","creation":"2021-03-24T02:09:27Z"},"accession":"S-BIAD56","cross_references":{"pubmed":["34312566"],"doi":["10.1038/s41592-021-01216-1"]}}