{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD609"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Study Component","organisation","Biosample","Image correlation","Associations","Image acquisition"],"pubmed_authors":["Roosmarijn E. Vandenbroucke","Arnout Bruggeman","Clint De Nolf","Charysse Vandendriessche","Elien Van Wonterghem","Junhua Xie","Lars Vereecke","Griet Van Imschoot"],"additional_accession":[]},"is_claimable":false,"name":"The importance of the blood-cerebrospinal fluid interface in the gut-brain axis and Aβ pathology","description":"In this study, we found that mice lacking gut microbiota displayed increased blood-cerebrospinal fluid (CSF) barrier permeability associated with disorganized tight junctions (TJs), which can be rescued by recolonization with gut microbiota or supplementation with short-chain fatty acids (SCFAs). We further confirmed that the vagus nerve plays an important role in this process but SCFAs can also bypass the vagus nerve and affect blood-CSF barrier functionality. Strikingly, the administration of SCFAs in AppNL-G-F AD mice also improved the localization of TJs in the blood-CSF barrier. This was accompanied by a pronounced reduction in β-amyloid (Aβ) burden, which could be achieved by regulating microglial phenotype. Altogether, our results suggest that modulating the microbiota or administer","dates":{"release":"2022-12-14T00:00:00Z","modification":"2023-01-14T20:09:46.908Z","creation":"2023-01-14T20:09:46.908Z"},"accession":"S-BIAD609","cross_references":{}}