{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"species":["Homo sapiens (human)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD621"],"repository":["bioimages"],"figure_sub":["Protocols","Study Component","organisation","Study Protocols"],"pubmed_authors":["Oliver Fackler"],"additional_accession":[]},"is_claimable":false,"name":"surce data fig 3b collagen from Gallucci et ","description":"Immature Dendritic Cells (iDCs) migrate in microenvironments with distinct cell and extracellular matrix densities in vivo and contribute to HIV-1 dissemination and mounting of antiviral immune responses. Here, we find that, compared to standard 2D suspension cultures, 3D collagen as tissue-like environment alters iDC properties and their response to HIV-1 infection. iDCs adopt an elongated morphology with increased deformability in 3D collagen at unaltered activation, differentiation, cytokine secretion or responsiveness to LPS. While 3D collagen reduces HIV-1 particle uptake by iDCs, fusion efficiency is increased to elevate productive infection rates due to elevated cell surface exposure of the HIV-1 binding receptor DC-SIGN. In contrast, 3D collagen reduces HIV transfer to CD4 T-cells ","dates":{"release":"2023-02-08T00:00:00Z","modification":"2023-02-08T20:28:43.196Z","creation":"2023-02-08T20:28:43.196Z"},"accession":"S-BIAD621","cross_references":{}}