bioimagesUnknownhttps://www.ebi.ac.uk/biostudies/studies/S-BIAD652bioimagesSpecimenStudy ComponentorganisationBiosampleAssociationsImage acquisitionFelipe CourtfalseSenescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injuryAfter peripheral nerve injuries, successful axonal growth and functional recovery requires the reprogramming of Schwann cells into a reparative phenotype, a process dependent on the activation of the transcription factor c-Jun. Nevertheless, axonal regeneration is greatly impaired in aged organisms or after chronic denervation leading to important clinical problems. This regenerative failure has been associated to a diminished c-Jun expression by Schwann cells, but whether the inability of these cells to maintain a repair state is associated to the transition into a phenotype inhibitory for axonal growth, has not been evaluated so far. We find that repair Schwann cells transitions into a senescent phenotype, characterized by diminished c-Jun expression and secretion of factor inhibitory fo2023-03-17T00:00:00Z2023-03-21T10:50:54.926Z2023-03-21T10:50:54.926ZS-BIAD652