{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BIAD859"],"repository":["bioimages"],"figure_sub":["Specimen","Image analysis","Study Component","organisation","Biosample","Image correlation","Associations","Image acquisition"],"pubmed_authors":["Graham Barlow","Paul Bollyky"],"additional_accession":[]},"is_claimable":false,"name":"High-Parameter Spatial Profiling of the Pancreas in Human Type 1 Diabetes","description":"In autoimmune Type 1 diabetes (T1D), immune cells progressively infiltrate and destroy the islets of Langerhans – islands of endocrine tissue dispersed throughout the pancreas. However, it is unclear how this process, called ‘insulitis’, develops and progresses within this organ. Here, using highly multiplexed CO-Detection by indEXing (CODEX) tissue imaging and cadaveric pancreas samples from autoantibody positive, T1D, and non-diabetic donors, we examine pseudotemporal-spatial patterns of insulitis and exocrine inflammation within large pancreatic tissue sections. ","dates":{"release":"2023-12-01T00:00:00Z","modification":"2025-03-26T13:24:37.091Z","creation":"2023-08-23T16:17:06.424Z"},"accession":"S-BIAD859","cross_references":{}}