bioimagesUnknownhttps://www.ebi.ac.uk/biostudies/studies/S-BIAD859bioimagesSpecimenImage analysisStudy ComponentorganisationBiosampleImage correlationAssociationsImage acquisitionGraham BarlowPaul BollykyfalseHigh-Parameter Spatial Profiling of the Pancreas in Human Type 1 DiabetesIn autoimmune Type 1 diabetes (T1D), immune cells progressively infiltrate and destroy the islets of Langerhans – islands of endocrine tissue dispersed throughout the pancreas. However, it is unclear how this process, called ‘insulitis’, develops and progresses within this organ. Here, using highly multiplexed CO-Detection by indEXing (CODEX) tissue imaging and cadaveric pancreas samples from autoantibody positive, T1D, and non-diabetic donors, we examine pseudotemporal-spatial patterns of insulitis and exocrine inflammation within large pancreatic tissue sections. 2023-12-01T00:00:00Z2025-03-26T13:24:37.091Z2023-08-23T16:17:06.424ZS-BIAD859