{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Thomas Blake"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST522"],"repository":["bioimages"],"additional_accession":["https://www.biorxiv.org/content/10.1101/2020.06.25.171900v1"],"figure_sub":["Organization","Experiment","Processed Data","Protocol"],"pubmed_authors":["Silvia Haase","Jake Baum","Thomas Blake"]},"is_claimable":false,"name":"Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum","description":"All symptoms of malaria disease are associated with the asexual blood stages of development, involving cycles of red blood cell (RBC) invasion and egress by the Plasmodium spp. merozoite. Merozoite invasion is rapid and is actively powered by a parasite actomyosin motor. The current accepted model for actomyosin force generation envisages arrays of parasite myosins, pushing against short actin filaments connected to the external milieu that drive the merozoite forwards into the RBC. In Plasmodium falciparum, the most virulent human malaria species, Myosin A (PfMyoA) is critical for parasite replication. However, the precise function of PfMyoA in invasion, its regulation, the role of other myosins and overall energetics of invasion remain unclear. Here, we developed a conditional mutagenesi","dates":{"release":"2020-11-01T00:00:00Z","modification":"2023-03-28T20:05:46.767Z","creation":"2020-10-14T11:36:00Z"},"accession":"S-BSST522","cross_references":{}}