bioimagesUnknownEster ZitoThe Journal of Cell Biologyhttps://www.ebi.ac.uk/biostudies/studies/S-JCBD-200911086JCB

Photomicrographs of crystal violet stained parental (P) Min6 cells following transduction with a blasticidin resistance-marked lentivirus<br />expressing either green fluorescent protein (GFP) or a fusion of GFP with a mutant proinsulinAkita GFP-INSC96Y (Liu et al., 2007). The transduced cells are also selected with Blasticidine.

Electron micrographs of insulin-producing beta cells from islets of Langerhans of wildtype

Fluorescent micrographs of frozen section of pancreas from <br />ERO1β homozygous mutant mice (i/i) stained with antisera to insulin (Ins) (green),glucagon(red), and the karyophilic dye DAPI(blue). Note the presence of glucagon positive cells in the interior of the islet of the ERO1β mutant.

Fluorescent micrographs of frozen section of pancreas from wildtype (+/+) stained with antisera to insulin (Ins) (green), ERO1β (red), and<br />the karyophilic dye DAPI (blue).

Electron micrographs of insulin-producing beta cells from islets of Langerhans of ERO1β mutant mice.Note the lack of ER dilation in the higher magnification views.

Photomicrographs of crystal violet stained ERO1β knockdown (KD1) Min6 cells following transduction with a blasticidin resistance-marked lentivirus expressing either green fluorescent protein (GFP) or a fusion of GFP with a mutant proinsulinAkita GFP-INSC96Y (Liu et al., 2007). The transduced cells are also selected with blasticidine.

Fluorescent micrographs of frozen section of pancreas from wildtype (+/+) and stained with antisera to insulin (Ins) (green), glucagon (red), and the karyophilic dye DAPI (blue).

Hematoxylin and eosin stained pancreatic sections of 3 month old wildtype and homozygous ERO1β mutant mice respectively.

Fluorescent micrographs of frozen section of pancreas from ERO1β homozygous mutant mice (i/i) stained with antisera to insulin (Ins) (green), ERO1β(red), and the karyophilic dye DAPI (blue).

bioimagesImage 9668 (Figure 4 - D)Image 9680 (Figure 7 - B)Figure 7 - BImage 9657 (Figure 4 - A)Image 9676 (Figure 7 - B)Figure 4 - AImage 9669 (Figure 4 - D)Image 9684 (Figure 4 - C)Image 9673 (Figure 7 - B)Image 9658 (Figure 4 - A)Figure 4 - CImage 9677 (Figure 7 - B)Figure 4 - DImage 9685 (Figure 4 - C)Image 9678 (Figure 7 - B)Image 9682 (Figure 2 - C)Image 9674 (Figure 7 - B)Image 9675 (Figure 7 - B)Figure 4Image 9670 (Figure 4 - D)Figure 7Image 9667 (Figure 4 - D)Image 9683 (Figure 2 - C)Figure 2 - CImage 9679 (Figure 7 - B)Figure 2King-Tung ChinDavid RonEster ZitoHeather P. HardingJaime BlaisfalseERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis2010-03-22T11:19:06Z2018-11-29T11:19:06Z2018-11-29T11:19:06ZS-JCBD-20091108610.1083/jcb.200911086