bioimagesUnknownArundhati Sengupta GhoshThe Journal of Cell Biologyhttps://www.ebi.ac.uk/biostudies/studies/S-JCBD-201103153JCB

Tuj1 staining in DLK (-/-) DRG explants. Caspase 9 is activated in many axons after 8 hours of NGF withdrawal in WT and cJun (lox/lox) neurons, but no activation is observed in DLK-/- neurons.

Immunohistochemical staining of lumbar level DRG from E17.5 DLK (-/-) littermates with a Pan-Trk antibody. DLK (-/-) DRGs (B) appear larger and contain more Trk positive neurons than WT controls (A).

Activated Caspase 9 staining in DLK (-/-) DRG explants. Caspase 9 is activated in many axons after 8 hours of NGF withdrawal in WT and cJun (lox/lox) neurons, but no activation is observed in DLK (-/-) neurons.

Activated Caspase 9 staining in cJun (lox/lox) DRG explants. Caspase 9 is activated in many axons after 8 hours of NGF withdrawal in WT and cJun (lox/lox) neurons.

Tuj1 staining in cJUN (lox/lox) DRG explants. Caspase 9 is activated in many axons after 8 hours of NGF withdrawal in WT and cJun (lox/lox) neurons.

Immunohistochemical staining of lumbar level DRG from E17.5 WT (DLK+/+) littermates with a Pan-Trk antibody. DLK (-/-) DLK (-/-) DRGs (B) appear larger and contain more Trk positive neurons than WT controls (A).

Activated Caspase 9 staining in DRG explants from cJun WT DRG explants. Caspase 9 is activated in many axons after 8 hours of NGF withdrawal in c Jun WT neurons.

Tuj1 staining in DRG explants from cJun WT. Caspase 9 is activated in many axons after 8 hours of NGF withdrawal in cJun WT neurons.

bioimagesFig 6 - OImage 32183 (Fig 6 - O)Fig 6 - MFig 6 - NImage 32176 (Fig 6 - M)Fig 7 - AFig 7 - BFig 7Fig 6Image 32179 (Fig 6 - N)Image 32180 (Fig 6 - O)Image 32177 (Fig 6 - M)Image 32182 (Fig 7 - B)Image 32181 (Fig 7 - A)Image 32178 (Fig 6 - N)Ryan J. WattsChristine D. PozniakBei WangMark ChenArundhati Sengupta GhoshJoseph W. LewcockfalseDLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity2011-09-05T11:22:03Z2018-11-29T11:22:03Z2018-11-29T11:22:03ZS-JCBD-20110315310.1083/jcb.201103153