{"database":"bioimages","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Gianluca Fulgenzi"],"journal":["The Journal of Cell Biology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-JCBD-201502100"],"attach_to":["JCB"],"legend":["Original image as generated by Gene Gnome gel scanner.<br />Original P-TrkB image","whole image of western blot as obtained from Gene Gnome gel scanner<br />Original chemiluminescent image with label that show part used in Fig 6A","Original image as generated by Gene Gnome gel scanner.<br />Original GAPDH image labeled to show part used in Fig 6C","TrkB in isolated cardiomyocytes part of Fig 1A. Original images digitalized from films","Complete image as obtained from Gene Gnome gel scanner.<br />Original externally illuminated  image to show marker","Original image as generated by Gene Gnome gel scanner.<br />Original P-TrkB image labeled to show part used in Fig 6C","Complete image as obtained from Gene Gnome gel scanner.<br />Original chemiluminescent image labeled to show part used in Fig 6B","whole image of western blot as obtained from Gene Gnome gel scanner<br />Original chemiluminescent image","Heart sections from a Rosa26floxedLacZ crossed with a Myh6-cre stained for B-galactosidase","GAPDH part of Fig 1A. Original images digitalized from films","Heart sections from a Rosa26floxedLacZ crossed with a Cdh5-cre transgenic mouse and stained for B-galactosidase.","Original image as generated by Gene Gnome gel scanner.<br />Original Total-TrkB image labeled to show part used in Fig 6C","TrkB WGA enriched part of Fig 1A. Original images digitalized from films with notes added.","Complete image as obtained from Gene Gnome gel scanner<br />Original chemiluminescent image with label added to show parts used in Fig 4I<br />Original externally illuminated image to show marker","TrkB in isolated cardiomyocytes part of Fig 1A. Original images digitalized from films with notes added.","TrkB inputs part of Fig 1A. Original images digitalized from films.","Complete image as obtained from Gene Gnome gel scanner<br />Original externally illuminated image to show markers","Complete image as obtained from Gene Gnome gel scanner<br />Original chemiluminescent image","Complete agarose gel of Fig 1C as obtained from reader","TrkB WGA enriched part of Fig 1A. Original images digitalized from films","Original image as generated by Gene Gnome gel scanner.<br />Original GAPDH image","GAPDH part of Fig 1A. Original images digitalized from films with notes added.","Original image as generated by Gene Gnome gel scanner.<br />Original Total-TrkB image","TrkB inputs part of Fig 1A. Original images digitalized from films with notes added.","Complete image as obtained from Gene Gnome gel scanner.<br />Original chemiluminescent image","whole image of western blot as obtained from Gene Gnome gel scanner<br />Original externally illuminated image to show markers","Heart sections from a Rosa26floxedLacZ (R26LacZ) mouse used as control stained for B-galactosidase"],"repository":["bioimages"],"figure_sub":["Image 629927 (Figure 1 - C)","Image 629933 (Figure 6 - A)","Image 629922 (Figure 1 - A)","Image 629936 (Figure 6 - B)","Image 629938 (Figure 6 - C)","Image 629930 (Figure 4 - I)","Image 629942 (Figure 6 - C)","Image 629928 (Figure 4 - I)","Image 629916 (Figure S4 - None)","Figure S4","Image 629917 (Figure S4 - None)","Image 629923 (Figure 1 - A)","Figure 4 - I","Image 629939 (Figure 6 - C)","Image 629919 (Figure 1 - A)","Image 629931 (Figure 6 - A)","Figure S4 - None","Image 629924 (Figure 1 - A)","Figure 1 - A","Image 629920 (Figure 1 - A)","Image 629940 (Figure 6 - C)","Image 629918 (Figure S4 - None)","Figure 1 - C","Figure 4","Image 629932 (Figure 6 - A)","Figure 6","Image 629925 (Figure 1 - A)","Image 629935 (Figure 6 - B)","Image 629937 (Figure 6 - C)","Image 629934 (Figure 6 - B)","Figure 6 - C","Image 629921 (Figure 1 - A)","Image 629926 (Figure 1 - A)","Figure 6 - A","Image 629941 (Figure 6 - C)","Figure 6 - B","Figure 1","Image 629929 (Figure 4 - I)"],"pubmed_authors":["Gianluca Fulgenzi","Jodi Becker","Lucia Babini","Lino Tessarollo","Sandrine Puverel","Francesco Tomassoni-Ardori","Colleen Barrick"],"additional_accession":[]},"is_claimable":false,"name":"BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation","description":"Brain-derived neurotrophic factor (BDNF) is critical for mammalian development and plasticity of neuronal circuitries affecting memory, mood, anxiety, pain sensitivity, and energy homeostasis. Here we report a novel unexpected role of BDNF in regulating the cardiac contraction force independent of the nervous system innervation. This function is mediated by the truncated TrkB.T1 receptor expressed in cardiomyocytes. Loss of TrkB.T1 in these cells impairs calcium signaling and causes cardiomyopathy. TrkB.T1 is activated by BDNF produced by cardiomyocytes, suggesting an autocrine/paracrine loop. These findings unveil a novel signaling mechanism in the heart that is activated by BDNF and provide evidence for a global role of this neurotrophin in the homeostasis of the organism by signaling through different TrkB receptor isoforms.","dates":{"release":"2015-09-07T11:27:15Z","modification":"2018-11-29T11:27:15Z","creation":"2018-11-29T11:27:15Z"},"accession":"S-JCBD-201502100","cross_references":{"doi":["10.1083/jcb.201502100"]}}