bioimagesUnknownSandra ScharawThe Journal of Cell Biologyhttps://www.ebi.ac.uk/biostudies/studies/S-JCBD-201601090JCBbioimagesImage 637061 (Figure 1 - B,D)Image 637045 (Figure 1 - B,D)Image 637106 (Figure 1 - B,D)Image 637027 (Figure 1 - B,D)Image 637053 (Figure 1 - B,D)Image 637096 (Figure 1 - B,D)Image 637086 (Figure 1 - B,D)Image 637122 (Figure 1 - B,D)Image 637043 (Figure 1 - B,D)Image 637114 (Figure 1 - B,D)Image 637078 (Figure 1 - B,D)Image 637035 (Figure 1 - B,D)Image 637055 (Figure 1 - B,D)Image 637047 (Figure 1 - B,D)Image 637068 (Figure 1 - B,D)Image 637071 (Figure 1 - B,D)Image 637094 (Figure 1 - B,D)Image 637092 (Figure 1 - B,D)Image 637108 (Figure 1 - B,D)Image 637029 (Figure 1 - B,D)Image 637116 (Figure 1 - B,D)Image 637081 (Figure 1 - B,D)Image 637084 (Figure 1 - B,D)Image 637076 (Figure 1 - B,D)Image 637063 (Figure 1 - B,D)Image 637037 (Figure 1 - B,D)Image 637110 (Figure 1 - B,D)Image 637102 (Figure 1 - B,D)Image 637083 (Figure 1 - B,D)Image 637048 (Figure 1 - B,D)Image 637030 (Figure 1 - B,D)Image 637056 (Figure 1 - B,D)Image 637039 (Figure 1 - B,D)Image 637091 (Figure 1 - B,D)Image 637109 (Figure 1 - B,D)Image 637098 (Figure 1 - B,D)Image 637080 (Figure 1 - B,D)Image 637117 (Figure 1 - B,D)Image 637072 (Figure 1 - B,D)Figure 1 - B,DImage 637064 (Figure 1 - B,D)Image 637067 (Figure 1 - B,D)Image 637075 (Figure 1 - B,D)Image 637041 (Figure 1 - B,D)Image 637059 (Figure 1 - B,D)Image 637033 (Figure 1 - B,D)Figure 1Image 637044 (Figure 1 - B,D)Image 637028 (Figure 1 - B,D)Image 637087 (Figure 1 - B,D)Image 637115 (Figure 1 - B,D)Image 637060 (Figure 1 - B,D)Image 637036 (Figure 1 - B,D)Image 637079 (Figure 1 - B,D)Image 637070 (Figure 1 - B,D)Image 637052 (Figure 1 - B,D)Image 637113 (Figure 1 - B,D)Image 637095 (Figure 1 - B,D)Image 637069 (Figure 1 - B,D)Image 637105 (Figure 1 - B,D)Image 637042 (Figure 1 - B,D)Image 637121 (Figure 1 - B,D)Image 637034 (Figure 1 - B,D)Image 637111 (Figure 1 - B,D)Image 637103 (Figure 1 - B,D)Image 637097 (Figure 1 - B,D)Image 637089 (Figure 1 - B,D)Image 637050 (Figure 1 - B,D)Image 637074 (Figure 1 - B,D)Image 637031 (Figure 1 - B,D)Image 637082 (Figure 1 - B,D)Image 637057 (Figure 1 - B,D)Image 637058 (Figure 1 - B,D)Image 637090 (Figure 1 - B,D)Image 637040 (Figure 1 - B,D)Image 637032 (Figure 1 - B,D)Image 637119 (Figure 1 - B,D)Image 637049 (Figure 1 - B,D)Image 637066 (Figure 1 - B,D)Image 637073 (Figure 1 - B,D)Image 637099 (Figure 1 - B,D)Image 637100 (Figure 1 - B,D)Image 637101 (Figure 1 - B,D)Image 637118 (Figure 1 - B,D)Image 637065 (Figure 1 - B,D)Image 637093 (Figure 1 - B,D)Image 637104 (Figure 1 - B,D)Image 637112 (Figure 1 - B,D)Image 637085 (Figure 1 - B,D)Image 637077 (Figure 1 - B,D)Image 637051 (Figure 1 - B,D)Image 637038 (Figure 1 - B,D)Image 637062 (Figure 1 - B,D)Image 637054 (Figure 1 - B,D)Image 637088 (Figure 1 - B,D)Image 637046 (Figure 1 - B,D)Image 637107 (Figure 1 - B,D)Image 637120 (Figure 1 - B,D)Murat IskarVibor LaketaFranck PerezIna PoserMartin BeckRainer PepperkokGaelle BoncompainEmma LundbergAlessandro OriPeer BorkSandra ScharawfalseThe endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFRStimulation of cells with epidermal growth factor (EGF) induces internalization and partial degradation of the EGF receptor (EGFR) by the endo-lysosomal pathway. For continuous cell functioning, EGFR plasma membrane levels are maintained by transporting newly synthesized EGFRs to the cell surface. The regulation of this process is largely unknown. In this study, we find that EGF stimulation specifically increases the transport efficiency of newly synthesized EGFRs from the endoplasmic reticulum to the plasma membrane. This coincides with an up-regulation of the inner coat protein complex II (COPII) components SEC23B, SEC24B, and SEC24D, which we show to be specifically required for EGFR transport. Up-regulation of these COPII components requires the transcriptional regulator RNF11, which l2016-11-08T11:28:58Z2018-11-29T11:28:58Z2018-11-29T11:28:58ZS-JCBD-20160109010.1083/jcb.201601090