{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=curation_notes.txt"],"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021.pdf"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021.svg"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021-biopax2.owl"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021_url.xml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=manifest.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021.vcml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=curation_image.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021.ode","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=metadata.rdf","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021-matlab.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021.sci","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021_url.sedml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000021?filename=BIOMD0000000021-octave.m"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Nicolas Le Novère"],"curationStatus":["Manually curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V1"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/BIOMD0000000021"],"publication_pubmed":["10366496"],"isPrivate":["false"],"repository":["BioModels"],"non_derived_xrefs":["BIOMD0000000171 biomodels.db"],"omics_type":["Models"],"modelFormat":["SBML"],"tokenised_name":["Leloup1999 CircClock"],"publication_year":["1999"],"submissionId":["MODEL6617834203"],"first_author":["Jean-Christophe Leloup"],"publication_authors":["Jean-Christophe Leloup, Goldbeter"],"publication":["10366496,\n In Drosophila, circadian oscillations in the levels of two proteins, PER and TIM, result from the negative feedback exerted by a PER-TIM complex on the expression of the per and tim genes which code for these two proteins. On the basis of these experimental observations, we have recently proposed a theoretical model for circadian oscillations of the PER and TIM proteins in Drosophila. Here we show that for constant environmental conditions this model is capable of generating autonomous chaotic oscillations. For other parameter values, the model can also display birhythmicity, i.e. the coexistence between two stable regimes of limit cycle oscillations. We analyse the occurrence of chaos and birhythmicity by means of bifurcation diagrams and locate the different domains of complex oscillatory behavior in parameter space. The relative smallness of these domains raises doubts as to the possible physiological significance of chaos and birhythmicity in regard to circadian rhythm generation. Beyond the particular context of circadian rhythms we discuss the results in the light of other mechanisms underlying chaos and birhythmicity in regulated biological systems. Copyright 1999 Academic Press.. 3, 198.\n Unite de Chronobiologie Theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C.P. 231, B-1050 Brussels, Belgium."],"submitter_mail":["lenov@ebi.ac.uk"],"submitter_affiliation":["EBML-EBI"],"publicationId":["BIOMD0000000021"],"pubmed_abstract":["In Drosophila, circadian oscillations in the levels of two proteins, PER and TIM, result from the negative feedback exerted by a PER-TIM complex on the expression of the per and tim genes which code for these two proteins. On the basis of these experimental observations, we have recently proposed a theoretical model for circadian oscillations of the PER and TIM proteins in Drosophila. Here we show that for constant environmental conditions this model is capable of generating autonomous chaotic oscillations. For other parameter values, the model can also display birhythmicity, i.e. the coexistence between two stable regimes of limit cycle oscillations. We analyse the occurrence of chaos and birhythmicity by means of bifurcation diagrams and locate the different domains of complex oscillatory behavior in parameter space. The relative smallness of these domains raises doubts as to the possible physiological significance of chaos and birhythmicity in regard to circadian rhythm generation. Beyond the particular context of circadian rhythms we discuss the results in the light of other mechanisms underlying chaos and birhythmicity in regulated biological systems. Copyright 1999 Academic Press."],"pubmed_title":["Chaos and birhythmicity in a model for circadian oscillations of the PER and TIM proteins in drosophila"],"pubmed_authors":["Leloup JC, Goldbeter A"],"pubmed_title_synonyms":["subgenus>, fruit fly, DmelCG3234, Drosophila Fallen, P60, 5.3.1.1, C77407, Proteins, Gene, genus>, tim, dtim, rit, TIM1, hTIM, Ritsu, GEF5, Protein, tim1, TPID, Gene Products, CHAOS, CG3234, dTIM, dTim, Flies, CPSRP43, 1823, Drosophila , TPI, Triose-phosphate isomerase, Drosophilas, mel_tim, Fly, fruit fly , T30B22.25, Drosophila Fruit Flies., CHLOROPLAST SIGNAL RECOGNITION PARTICLE 43, Fruit Flies, Protein Gene Products, Drosophila Fruit, Gene Proteins, Drosophila, Drosophila Fruit Fly, HEL-S-49, Debt69, Fruit Fly, fruit flies, TIM, Tim, Drosophila , fruit fly, Drosophila Fallen, Materials, T22F8.160, cycline, experimental, P60, and rna binding 2, Processes, DmcyclinE, fond, Twenty-Four Hour Rhythm, Gene, cycE, Visible Light, circadian rhythm, Nycthemeral Rhythms, CycEI, rit, l(2)br37, and RNA binding 1, CYCLE, hTIM, Ly113, cdi7, Ccne, cyclinE, T22F8_160, GEF5, Twenty-Four Hour Rhythms, Diurnal, ATGPR7, Gene Products, Cdi7, CDI7, circadian response, CG3234, GRP8, GRP7, Flies, Circadian, Diurnal Rhythms, methods, CYCE, Genetic, Nycthemeral Rhythm, occurrence, TPI, Triose-phosphate isomerase, experimental section, DmelCG3938, Drosophilas, CyclE, prevalence, Fly, 3938, T30B22.25, Visible, DmcycE, Drosophila Fruit, l(2)k05007, dm-cycE, TNFSF14, Rhythm, ATGRP7, GLYCINE RICH PROTEIN 7, ATGRP8, Rhythms, Debt69, TR2, fruit flies, Behaviors, glycine-rich RNA-binding protein 8, TIM, Tim, Nycthemeral, incidence, single-organism behavior, lumen, DmelCG3234, Radiation, Process, UNQ391/PRO726, 5.3.1.1, C77407, space, frequency, Proteins, Nyctohemeral Rhythms, genus>, Light, tim, Cyc E, br37, dtim, Cistrons, CD258, results, TIM1, Acceptance Processes, Nyctohemeral, Twenty Four Hour Rhythm, Copyrights., Acceptance Process, l(2)k02514, LIGHT, DmCycE, BG:DS07108.3, Ritsu, Protein, tim1, TPID, CHAOS, Genetic Materials, CyeE, GLYCINE-RICH RNA-BINDING PROTEIN 7, anatomical spaces, l(2)05206, dTIM, dTim, outbreaks, Genetic Material, CPSRP43, 1823, GLYCINE-RICH PROTEIN 8, Visible Radiations, Radiations, Acceptance, Drosophila , lumen space, Visible Radiation, l(2)k02602, HVEML, cold, Twenty-Four Hour, Circadian Rhythms, HVEM-L, Diurnal Rhythm, l(2)35Dd, GR-RBP7, Photoradiation, fruit fly , mel_tim, GR-RBP8, CHLOROPLAST SIGNAL RECOGNITION PARTICLE 43, surveillance, morbidity, endemics, LTg, Fruit Flies, experimental procedures, Protein Gene Products, Gene Proteins, D-CycE, Drosophila, l35Dd, Photoradiations, F2G1.4, Material, Drosophila Fruit Fly, HEL-S-49, twenty-four hour rhythm, Fruit Fly, Cistron, epidemics, response to circadian rhythm, Feedbacks, diurnal rhythm, CG3938, Nyctohemeral Rhythm, Drosophila