{"database":"BioModels","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=curation_notes.txt"],"Pdf":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077.pdf"],"Owl":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077-biopax3.owl","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077-biopax2.owl"],"Svg":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077.svg"],"Xml":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=manifest.xml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077_url.xml"],"Other":["https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=curation_image.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077_url.sedml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077.png","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077-matlab.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077-octave.m","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077.ode","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=BIOMD0000000077.vcml","https://www.ebi.ac.uk/biomodels/model/download/BIOMD0000000077?filename=metadata.rdf"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Enuo He"],"curationStatus":["Manually curated"],"modellingApproach":["ordinary differential equation model"],"levelVersion":["L2V4"],"full_dataset_link":["https://www.ebi.ac.uk/biomodels/BIOMD0000000077"],"publication_pubmed":["10662710"],"isPrivate":["false"],"repository":["BioModels"],"modelFormat":["SBML"],"omics_type":["Models"],"tokenised_name":["Blum2000 LHsecretion 1"],"publication_year":["2000"],"submissionId":["MODEL3092061764"],"publication_authors":["J J Blum, M C Reed, J A Janovick, P M Conn"],"first_author":["J J Blum"],"publication":["10662710,\n                            A mathematical model is developed to investigate the rate of release of luteinizing hormone (LH) from pituitary gonadotropes in response to short pulses of gonadotropin-releasing hormone (GnRH). The model includes binding of the hormone to its receptor, dimerization, interaction with a G protein, production of inositol 1,4, 5-trisphosphate, release of Ca(2+) from the endoplasmic reticulum, entrance of Ca(2+) into the cytosol via voltage-gated membrane channels, pumping of Ca(2+) out of the cytosol via membrane and endoplasmic reticulum pumps, and release of LH. Cytosolic Ca(2+) dynamics are simplified (i.e., oscillations are not included in the model), and it is assumed that there is only one pool of releasable LH. Despite these and other simplifications, the model explains the qualitative features of LH release in response to GnRH pulses of various durations and different concentrations in the presence and absence of external Ca(2+).. 2, 278.\n                            Department of Cell Biology, Duke University Medical Center, Durham 27710, North Carolina, USA. j.blum@cellbio.duke.edu"],"submitter_mail":["enuo.he@wolfson.ox.ac.uk"],"submitter_affiliation":["University of Oxford"],"publicationId":["BIOMD0000000077"],"pubmed_abstract":["A mathematical model is developed to investigate the rate of release of luteinizing hormone (LH) from pituitary gonadotropes in response to short pulses of gonadotropin-releasing hormone (GnRH). The model includes binding of the hormone to its receptor, dimerization, interaction with a G protein, production of inositol 1,4, 5-trisphosphate, release of Ca(2+) from the endoplasmic reticulum, entrance of Ca(2+) into the cytosol via voltage-gated membrane channels, pumping of Ca(2+) out of the cytosol via membrane and endoplasmic reticulum pumps, and release of LH. Cytosolic Ca(2+) dynamics are simplified (i.e., oscillations are not included in the model), and it is assumed that there is only one pool of releasable LH. Despite these and other simplifications, the model explains the qualitative features of LH release in response to GnRH pulses of various durations and different concentrations in the presence and absence of external Ca(2+)."],"pubmed_title":["A mathematical model quantifying GnRH-induced LH secretion from gonadotropes."],"pubmed_authors":["Blum J J JJ, Reed M C MC, Janovick J A JA, Conn P M PM"],"pubmed_abstract_synonyms":["HH12, hypophysis cerebri, 6-cyclohexanehexol, gland, pituitary body, Dimerizations, myo-inositol, number, FSH-Releasing Hormone, LFRH, Dambose, Gene, inflammation of pituitary gland, protein, FSH Releasing Hormone, hypophysis, protein-containing complex, LNRH, presence, Kryptocur, Hormone, pituitary, Meat sugar, Membrane Tissues, Hp, Ca2+, Mesoinositol, i-inositol, integral component of membrane, Ionic Channels, Gene Products, 1, 2, 3, 4, 5, protein aggregate, Agonists, Ionic, Pulses, Cyclohexitol, Chiro Inositol, D-myo-Inositol, inosite, hormones, Gnrh2, Hormone Receptor, CALCIUM ION, Ion Channel, Tissues, Luteozyman, Cystorelin, ligand, LHFSH, absent from organism, membrane region, Tissue, Lutropin, Luteoziman, L-myo-Inositol, stubby, myo-Inositol, Hormone Receptor Agonists, GnRH, Gnrh, Rgnrhg1, hpg, endocrine, Releasing Hormone, 2R, Gonadotropin Releasing Hormone, glandula pituitaria, LH FSH Releasing Hormone, hypophysitides, Luteinizing Hormone-Releasing Hormone, Luteinizing Hormone Releasing Hormone, Ionic Channel, Bios I, region of membrane, nervous system, LH-FSH Releasing Hormone, Membrane Channel, LHFSH Releasing Hormone, Gonadorelin, LH-RH, ICSH (Interstitial Cell Stimulating Hormone), GNRH, Lnrh, Gonadorelin Acetate, Luteinizing, 3S, Membrane Tissue, CALCIUM ION., membrane, 5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (human or pig), (1r, 6S)-cyclohexane-1, protein complex, Ergastoplasm, Interstitial Cell Stimulating Hormone, Proteins, LHRH, 5-trans-4, integral to membrane, cis-1, Receptor Agonists, Luteinizing hormone, Gnrha, doubly charged positive ion, Reticulum, LH (Luteinizing Hormone), shortened, LHFSHRH, Inositol, 6-hexol, count in organism, Gn-RH, Channel, native protein, inositol, response to GnRH, ER, Gonadorelin Hydrochloride, Factrel, Protein, whole membrane, GRH, 5R, 4s, Lhrh1, 1L-myo-Inositol, transmembrane, absence, 1D-myo-Inositol, pituitary gland, Channels, Ins, Chiro-Inositol, Myoinositol, Luliberin, Membrane Channels, Ca(2+), Interstitial Cell-Stimulating Hormone, Membrane, 5/4, Dirigestran, Protein Gene Products, Gene Proteins, inositols, calcium, meso-Inositol, Gonadoliberin, Endoplasmic, Ion, pituitary gland inflammation, 6-HEXAHYDROXY-CYCLOHEXANE, Cytosols, LH-Releasing Hormone, Lhrh, short, Interstitial Cell-Stimulating, LH Releasing Hormone"],"description_synonyms":["HH12, biochemical pathways, exocrine gland fluid, YB, exocrine gland fluid or secretion, Effects, developmental stage, AUTSX5, number, FSH-Releasing Hormone, LFRH, Copyrights, NOVH, FSH Releasing Hormone, CCN3, LNRH, QM, presence, Kryptocur, Long Term, Hormone, acides nucleiques, Yb, Agonists, Effect, CG2706, fs(1)M104, hormones, Gnrh2, Hormone Receptor, Longterm, catabolism, Cystorelin, LHFSH, Bodily, Hormone Receptor Agonists, Long-Term, IGFBP9, GnRH, Gnrh, Rgnrhg1, free, hpg, endocrine, Releasing Hormone, IBP-9, Gonadotropin Releasing Hormone, LH FSH Releasing Hormone, secreted substance, Kiaa4053, Secretion, acidos nucleicos, bodily secretion, Luteinizing Hormone-Releasing Hormone, L10, Secretions, Luteinizing Hormone Releasing Hormone, biotransformation, LH-FSH Releasing Hormone, stage, Long-Term Effect, LHFSH Releasing Hormone, Gonadorelin, LH-RH, NOVh, Long-Term Effects, GNRH, Lnrh, Gonadorelin Acetate, Papers, 5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (human or pig), degradation, acide nucleique, external secretion, DmelCG2706, LHRH, Longterm Effect, DXS648, Receptor Agonists, Gnrha, LHFSHRH, exocrine gland fluid/secretion, Bodily Secretion, count in organism, Gn-RH, IGFBP-9, nucleic acids, Nucleic Acid, Gonadorelin Hydrochloride, Factrel, Long Term Effects, secretion, NA, NOV, PlexA1, Nucleic., GRH, Data Base, Lhrh1, Acid, Plxn1, Nukleinsaeure, biodegradation, Luliberin, nov, acido nucleico, mKIAA4053, fs(1)Y[b], Nucleic, Dirigestran, Longterm Effects, Gonadoliberin, concentration, C130088N23Rik, Nukleinsaeuren, EG:95B7.8, LH-Releasing Hormone, 2600013D04Rik, PLXN1, Acids, Lhrh, DXS648E, exocrine gland secretion, LH Releasing Hormone"],"pubmed_title_synonyms":["HH12, biochemical pathways, 5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (human or pig), exocrine gland fluid, degradation, exocrine gland fluid or secretion, external secretion, LHRH, FSH-Releasing Hormone, LFRH, FSH Releasing Hormone, Gnrha, LNRH, Kryptocur, LHFSHRH, exocrine gland fluid/secretion, Bodily Secretion, Gn-RH, Gonadorelin Hydrochloride, Factrel, secretion, exocrine gland secretion., GRH, Lhrh1, Gnrh2, biodegradation, catabolism, Cystorelin, LHFSH, Luliberin, Bodily, GnRH, Gnrh, Rgnrhg1, Dirigestran, hpg, Releasing Hormone, Gonadotropin Releasing Hormone, LH FSH Releasing Hormone, secreted substance, Secretion, Gonadoliberin, bodily secretion, Luteinizing Hormone-Releasing Hormone, Secretions, Luteinizing Hormone Releasing Hormone, biotransformation, LH-Releasing Hormone, LH-FSH Releasing Hormone, LHFSH Releasing Hormone, Gonadorelin, Lhrh, LH-RH, GNRH, Lnrh, LH Releasing Hormone, Gonadorelin Acetate"],"additional_accession":[]},"is_claimable":false,"name":"Blum2000_LHsecretion_1","description":"\n      \n        \n          A mathematical model quantifying GnRH-induced LH secretion from gonadotropes by Blum et al (2000)\n        \n        This paper includes three stages, and the model does not include the third stage. Also an event is included which remove the hormone GnRH at time=5min. Figure 1 and Figure 2 of the paper are reproduced, using SBML odeSolver. We choose to encode the model with the concentration of GnRH equal to 1.0nM.\n        This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.For more information see the terms of use.To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.\n      \n    \n  ","dates":{"last_modification":"2024-08-21","publication":"2024-09-02","submission":"2006-11-21"},"accession":"BIOMD0000000077","cross_references":{"pubmed":["10662710"],"chebi":["CHEBI:16595"],"pirsf":["PIRSF005483"],"biomodels__db":["MODEL3092061764","BIOMD0000000077"],"go":["GO:0032275","GO:0007200","GO:0097210","GO:0005623","GO:0043234","GO:0005834","GO:0005220","GO:0051428","GO:0005102","GO:0004968","GO:0006461","GO:0007202","GO:0009056","GO:0004629","GO:0046888"],"kegg__compound":["C01245"],"taxonomy":["131567"],"uniprot":["P51924","P07490","P30969"],"interpro":["IPR000699"]}}